Regularly Appraise individuals, specifically when initiating and titrating acetaminophen and codeine phosphate tablets and when acetaminophen and codeine phosphate tablets are given concomitantly with other medicine that depress respiration (see WARNINGS). Alternatively, think about the usage of non-opioid analgesics in these clients.
Emphasize to clients and their caregivers the value of looking through the Medication Guide that they may obtain from their pharmacist when an opioid analgesic is dispensed to them.
The concomitant utilization of acetaminophen and codeine phosphate tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may cause an increase in codeine plasma concentrations as well as a lessen in active metabolite morphine plasma focus which could lead to an analgesic efficacy reduction or indications of opioid withdrawal.
Mix acetaminophen and codeine phosphate tablets (don't crush) with an unpalatable compound such as dirt, cat litter, or utilized coffee grounds;
Acetaminophen and codeine could trigger extreme hypotension like orthostatic hypotension and syncope in ambulatory sufferers. There exists enhanced chance in people whose ability to take care of hypertension has now been compromised by a diminished blood quantity or concurrent administration of selected CNS depressant medicine (e.g., phenothiazines or general anesthetics) (see Safeguards, Drug Interactions).
Speak with your healthcare supplier Should the suffering you have improves, if you really feel extra delicate to discomfort, or In case you have new soreness immediately after using acetaminophen and codeine phosphate tablets.
Notify people that opioids could induce a scarce but probably lifestyle-threatening problem resulting from concomitant administration of serotonergic medicines. Warn patients from the indications and signs of serotonin syndrome and to hunt medical attention without delay if signs and symptoms build.
Rapid discontinuation has also been related to makes an attempt to find other sources of opioid analgesics, which may be puzzled with drug-trying to find for abuse. People may also try to take care of their suffering or withdrawal signs or symptoms with illicit opioids, for instance heroin, and various substances.
Vigorous supportive therapy is needed in extreme intoxication. Procedures to Restrict the continuing absorption with the drug need to be quickly carried out For the reason that hepatic harm is dose-dependent and happens early in the midst of intoxication.
Instruct patients to not share acetaminophen and codeine phosphate tablets with Other individuals and to take techniques to safeguard acetaminophen and codeine phosphate tablets from theft or misuse.
Due to the website challenges affiliated with accidental ingestion, misuse, and abuse, advise sufferers to retail outlet acetaminophen and codeine phosphate tablets securely, outside of sight and arrive at of children, and in a site not obtainable by Other people, like people to check here the house (see WARNINGS and DRUG ABUSE AND DEPENDENCE).
Discontinuation of a concomitantly used check here cytochrome P450 2D6 inhibitor may possibly result in a lessen website in codeine plasma focus and an increase in Lively click here metabolite morphine plasma concentration which could maximize or extend adverse reactions and may lead to perhaps deadly respiratory melancholy.
Acetaminophen and codeine phosphate tablets are contraindicated for all young children youthful than 12 a long time of age (see CONTRAINDICATIONS).
Under no circumstances give any person else your acetaminophen and codeine phosphate tablets. They may die from using it. Advertising or freely giving acetaminophen and codeine phosphate tablets is against the legislation.